Monoclonal antibody to Collagen Type IV Alpha 5 (COL4a5), derived from recombinant COL4a5(Gly1461~Thr1685), is reactive with Human/Mouse/Rat.
- High specificity, affinity and purity
- Extensive validation and batch-to-batch consistency
- Diverse range of conjugated and custom options
- Comprehensive validation data and documentation
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COL4a5 is one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Three transcript variants have been identified for this gene. Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please proper stored each component based on the instruction.
Type: Primary
Antigen: COL4a5
Clonality: Monoclonal
Clone: 7#
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human, Mouse, Rat