Monoclonal Antibody to Apolipoprotein A4 (APOA4), derived from recombinant APOA4 (Glu21~Asn235), is reactive with Human/Pig.
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APOA4 resides on chromosome 11 in close linkage to APOA1 and APOC3. APOA4 contains 3 exons separated by two introns, and is polymorphic, although most of the reported sequence polymorphisms occur in exon 3. The best validated and studied non-synonymous SNPs are a glutamine histidine substitution at codon 380 and a threonine serine substitution at codon 367; a sequence polymorphism has also been identified in the 3'UTR of the third exon. Intra-species comparative gene sequence analysis suggests that the APOA4 gene arose from APOA1 by gene duplication approximately 270 MYA.The primary translation product of the APOA4 gene is a 396-residue preprotein, which undergoes proteolytic processing to yield apo A-IV, a 376-reside mature O-linked glycoprotein.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please properly store each component based on the instruction.
Type: Primary
Antigen: APOA4
Clonality: Monoclonal
Clone: A8
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b Kappa
Reactivity: Human, Pig