Monoclonal Antibody to Hemoglobin Alpha 1 (HBa1), derived from recombinant HBa1 (Met1~Arg142), is reactive with Human/Rat.
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The human alpha globin gene cluster located on chromosome 16 spans about 30 Kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please properly store each component based on the instruction.
Type: Primary
Antigen: HBa1
Clonality: Monoclonal
Clone: C5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human, Rat