Anti-DNASE1 Mouse Monoclonal Antibody [clone: 2-1#]

Supplier: CLOUD-CLONE CORP MS
MAB127HU22
MSPP-MAB127HU2EA 352 USD
MSPP-MAB127HU2
Anti-DNASE1 Mouse Monoclonal Antibody [clone: 2-1#]
Antibodies
Monoclonal Antibody to Deoxyribonuclease I (DNASE1), derived from recombinant DNASE1 (Gly19~Ala259), is reactive with Human.

  • High specificity, affinity and purity
  • Extensive validation and batch-to-batch consistency
  • Diverse range of conjugated and custom options
  • Comprehensive validation data and documentation
  • All in stock and fast global delivery
  • 100% Quality and service satisfaction guarantee

DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. It has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. DNase I binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. The function of this interaction is unclear. However since actin-bound DNase I is enzymatically inactive, the DNase-actin complex might be a storage form of DNase I that prevents damage of the genetic information.

Caution: For research use only. Not for use in clinical diagnostic procedures. Please proper stored each component based on the instruction.

Type: Primary
Antigen: DNASE1
Clonality: Monoclonal
Clone: 2-1#
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR