Anti-PARP Mouse Monoclonal Antibody [clone: C2]

Supplier: CLOUD-CLONE CORP MS
MAA279HU21
MSPP-MA279HU21EA 336 USD
MSPP-MA279HU21
Anti-PARP Mouse Monoclonal Antibody [clone: C2]
Antibodies
Monoclonal Antibody to Poly ADP Ribose Polymerase (PARP), derived from recombinant PARP (Asp788~Trp1014), is reactive with Human.

  • High specificity, affinity and purity
  • Extensive validation and batch-to-batch consistency
  • Diverse range of conjugated and custom options
  • Comprehensive validation data and documentation
  • All in stock and fast global delivery
  • 100% Quality and service satisfaction guarantee

is a protein involved in a number of cellular processes involving mainly DNA repair and programmed cell death. RP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitroand is one of the main cleavage targets of caspase-3in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP1 is a chromatin-associated enzyme, poly-ADP ribose polymerase-1, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks.

Caution: For research use only. Not for use in clinical diagnostic procedures. Please proper stored each component based on the instruction.

Type: Primary
Antigen: PARP
Clonality: Monoclonal
Clone: C2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 Kappa
Reactivity: Human
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