Biotin-Linked Monoclonal Antibody to Collagen Type VII (COL7), derived from recombinant COL7 (Pro190~Asp472), is reactive with Human.
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Collagen, type VII, alpha 1 encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an autoimmune response against type VII collagen can result in an acquired form of this disease called epidermolysis bullosa acquisita. Type VII collagen is also found in the retina; its function in this organ is unknown. COL7A1 is located on the short arm of human chromosome 3, in the chromosomal region denoted 3p21.31.
Caution: For research use only. Not for use in clinical diagnostic procedures. Please proper stored each component based on the instruction.
Type: Primary
Antigen: COL7
Clonality: Monoclonal
Clone: C9
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human
