Apicidin ≥99% (by HPLC, TLC)

Supplier: Enzo Life Sciences

Synonyms: cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]

BML-GR340-0005
89158-970EA 98.1 USD
89158-970 89158-972
Apicidin ≥99% (by HPLC, TLC)
Apicidin

HDAC inhibitor


Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest at the G1 phase. At 100nM it induces a long lasting hyperacetylation of histone H4 while that induced by trichostatin is transient. Stimulates apoptosis. Apoptosis is induced via induction of Fas/Fas ligand. Displays potent antiangiogenic effects and dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines. Antiprotozoal.

Formula: C₃₄H₄₉N₅O₆
MW: 623.8 g/mol
CAS Number: 183506-66-3

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