Baicalein ≥98% (by TLC)
Supplier: Enzo Life Sciences
Synonyms:
5,6,7-Trihydroxyflavone, 5,6,7-Trihydroxy-2-phenyl-4H-chromen-4-one, 5,6,7-Trihydroxy-2-phenylchromen-4-one
Lipoxygenase inhibitor
Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes. Inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (POP/PREP)(IC50=36µM).
Formula:
C₁₅H₁₀O₅ |
MDL Number:
MFCD00017459 CAS Number: 491-67-8 |
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