Anti-LAG3 Mouse Monoclonal Antibody (Biotin)

Supplier: Enzo Life Sciences

Anti-LAG3 Mouse Monoclonal Antibody (Biotin)

Anti-LAG3 Mouse Monoclonal Antibody (Biotin)

804-806B-C100

89155-006EA 722.67 USD

89155-006

Anti-LAG3 Mouse Monoclonal Antibody (Biotin)

Antibodies

The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses.

For ELISA, Flow Cytometry

Recognizes the 30 aa extra-loop of the first N-terminal D1 domain of human LAG-3.

Type: Primary
Antigen: LAG3
Clonality: Monoclonal
Clone:
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human

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