Neomycin sulfate
Supplier: Enzo Life Sciences
Synonyms:
Neomycin, Fradiomycin sulfate, (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulphate, Fradiomycin sulphate, Neomycin sulphate salt, Neomycin sulfate salt, (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulfate
Inhibitor of PLC and PLD.
Aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Inhibitor of phospholipase C (PLC; IC50=1-10µM) due to binding to inositol phospholipids. Neomycin inhibits phosphatidylcholine-phospholipase D activity (IC50=65µM). Blocks voltage sensitive Ca2+ channels without affecting Na+/Ca2+ antiporters in nerve cells. Induces PLA2 activation in human platelets.
Formula:
C₂₃H₄₆N₆O₁₃·3H₂SO₄ MW: 908.87 g/mol |
MDL Number:
MFCD00150827 CAS Number: 1405-10-3 |
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