A water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers (solubility in PBS ~ 40 mM; micelle MW ~ 23,100; aggregation number ~ 8.1; partial specific volume ~ 0.77 cm3/g). Shown to not only solubilize but also stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~ 250 µM and [protein] ~ 22 µM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.
A water soluble, amphiphilic α-helical, non-denaturing lipopeptide detergent (LPD) that forms small micelles (CMC <1 µM; micelle MW ~23,100; aggregation number ~8.1; partial specific volume ~0.77 cm3/g) and effectively mimics lipid bilayers. Shown to solubilize as well as stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~250 µM and [protein] ~22 µM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.
Sequence: Ac-Ala-Orn(dodecanoyl)-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Lys-Tyr-Ala-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Lys-Ala-Orn(dodecanoyl)-Ala-NH₂
Supplied as a trifluoroacetate salt.
Following reconstitution, aliquot and freeze (–20°C). Stock solutions are stable for up to 3 months at –20°C.
Packaging: Packaged under inert gas
Caution: Toxicity: Irritant (B)
