1,9-Pyrazoloanthrone ≥98% (by HPLC), Sigma-Aldrich®

Supplier: MilliporeSigma

Synonyms: JNK Inhibitor II, Anthra[1,9-cd]pyrazol-6(2H)-one, Dibenzo[cd,g]indazol-6(2H)-one, SP600125, SP 600125

Packaged under inert gas.

420119-5MG
80600-290EA 114.29 USD
80600-290
1,9-Pyrazoloanthrone ≥98% (by HPLC), Sigma-Aldrich®
1,9-Pyrazoloanthrone

A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP.


Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.

Formula: C₁₄H₈N₂O
MW: 220.231 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00022289
CAS Number: 129-56-6

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Specification Test Results

Purity ≥98% (HPLC)

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