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DepleteX® RNA Depletion (Globin)

Supplier: REVVITY HEALTH SCIENCES, INC.

DepleteX® RNA Depletion (Globin)

DepleteX® RNA Depletion (Globin)

NOVA-512870

77575-226EA 1236 USD

77575-226

DepleteX® RNA Depletion (Globin)

Nucleic Acid Reagents Next Generation Sequencing Reagents

The DepleteX® globin depletion kit selectively removes highly expressed globin transcripts (HBA1, HBA2, HBB, and HBD) in vitro before sequencing.

Unbiased removal of human globin from RNA-seq libraries
Achieve >99% depletion of contaminating globin
Rapid one-hour depletion incubation

Enhance RNA-Seq quality by eliminating globin fragments. Apart from ribodepletion, RNA samples often contain a limited number of well-characterized, highly expressed transcripts. However, resequencing these transcripts contributes minimally to biologically relevant information. The dominance of highly expressed transcripts hinders coverage for low-expressing counterparts, resulting in reduced sensitivity for detecting disease-related low-expressing genes, rare variants, and unique fusion events.

Globin mRNA dominates the mRNA content of red blood cells and whole blood. Three globlin genes (HBA1, HBA2 and HBB) constitute ≥30% of total mRNA from blood.

Certifications: Manufactured in ISO 9001 facility.

Caution: For research use only. Not for use in diagnostic procedures.

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