Mismatch Endonuclease I, New England Biolabs

Supplier: New England Biolabs (NEB)

Mismatch Endonuclease I M0678S

Mismatch Endonuclease I M0678S

M0678S

76509-466EA 162 USD

76509-466

Mismatch Endonuclease I, New England Biolabs

Enzymes

Mismatch Endonuclease I is a Mg²⁺ dependent DNA endonuclease that specifically cleaves mismatched base pairs (T:T, G:G and T:G mismatches).

Recognizes and cleave T:T, G:G and T:G mismatches in DNA
Cleaves the 3rd phosphodiester bond on the 5' side of the mismatched base in both strands
Cleaves a 5 bp overhang with a 3'-OH and 5'-phosphate
Best at T mismatches and does not recognize all DNA mismatches
Isolated from a recombinant source
Concentration: 80000 units/ml

Mismatch Endonuclease I cleaves the 3rd phosphodiester bond on the 5' side of the mismatched base in both strands, leaving a 5 bp overhang. While Mismatch Endonuclease I prefers to cleave T:T, G:G and T:G DNA mismatches, it will also readily cleave T:I, G:I and G:U DNA mismatches. Additionally, Mismatch Endonuclease I has been shown to nick the thymine containing strand of T:C DNA mismatches, and cleave T:G and T:U (DNA:RNA) mismatches albeit to a lesser extent than DNA:DNA mismatches.

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