Anti-IL1R2 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

AntiHMN IL-1 receptor type II 1M

AntiHMN IL-1 receptor type II 1M

109-401-305S

76234-802EA 151.49 USD

76234-802

Anti-IL1R2 Rabbit Polyclonal Antibody

Antibodies

Interleukin-1 Receptor Type 2 (IL-1RII) ins a non-signaling receptor for IL1A, IL1B and IL1RN and reduces IL1B activities. It serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. It also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

This antiserum against Human IL-1 Receptor Type II (IL-1RII) has been tested for use in ELISA, radioimmunoassays and immunoprecipitation. Reactivity in other immunoassays is unknown. IL-1RII has been termed p68 or CD121 in some laboratories. IL-1RII has been shown to bind IL-1, IL-1a and IL-1b.

Type: Primary
Antigen: IL1R2
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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