Anti-ATG12 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Supplier: Bioss

BS-4012R-A750

76085-594EA 753.79 USD

76085-594

Anti-ATG12 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Antibodies

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

Type: Primary
Antigen: ATG12
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-187/187
Host: Rabbit
Isotype: IgG
Reactivity: Mouse; Rat

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