Anti-DDX58 Thr170 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Supplier: Bioss

BS-5300R-A680

76080-158EA 753.8 USD

76080-158

Anti-DDX58 Thr170 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Antibodies

The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.

Type: Primary
Antigen: DDX58 Thr170
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse

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