Mouse Recombinant sRANK (from CHO cells)

Supplier: Peprotech

315-11C-1MG 315-11C-2UG 315-11C-10UG 315-11C-50UG 315-11C-100UG 315-11C-250UG 315-11C-500UG
75999-406EA 7996.55 USD
75999-406 75999-626 75999-628 75999-630 75999-632 75999-634 75999-636
Mouse Recombinant sRANK (from CHO cells)
Proteins and Peptides

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Murine sRANK Ligand is a 19.8 kDa polypeptide comprising the TNF-homologous region of RANKL (178 amino acid residues).

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