Anti-BBC3 Mouse Monoclonal Antibody [Clone: [2A8F6]]

Supplier: Rockland Immunochemical
200-301-DV3
75935-054EA 739.7 USD
75935-054
Anti-BBC3 Mouse Monoclonal Antibody [Clone: [2A8F6]]
Antibodies
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAa and PUMAb. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Anti-PUMA Antibody has been tested for use in ELISA and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 21 kDa in Western Blots of specific cell lysates and tissues.

Type: Primary
Antigen: BBC3
Clonality: Monoclonal
Clone: [2A8F6]
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity:
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