Lmtk3

Supplier: Rockland Immunochemical

010-001-S39S

75934-862EA 388.66 USD

75934-862 75934-864

Lmtk3

Proteins and Peptides

LMTK3 protein GST fusion

Control Protein
PCA Assays
ImmunoBlot

LMTK3, or Lemur tyrosine kinase 3, belongs to the LMR subfamily of tyr protein kinases. LMTK3 decreases the activity of protein kinase C (PKC) and also leads to phosphorylation of AKT (Ser473), thereby increasing binding of forkhead box O3 (FOXO3) to the ESR1 promoter. LMTK3 phosphorylates ERα, protecting it from proteasomal degradation in vitro. Knockdown of LMTK3 leads to a reduction of tumor volume in an orthotopic mouse model and abrogates proliferation of ERα+ but not ERα- cells, indicative of its role in ERα activity. These findings reveal LMTK3 as a new therapeutic target for breast cancer (1). LMTK3 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, and Ser/Thr Kinases research.

LMTK3 Protein is stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. LMTK3 Protein is suitable for use in Western Blot. Expect a band approximately ~75kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

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