TUBB
Supplier: Rockland Immunochemical
Tubulin Beta (TUBB1) control protein-GST fusion
- Control Protein
- PCA Assays
- ImmunoBlot
TUBB1 or tubulin-beta 1 protein is a major constituent of microtubules. TUBB1 interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function (1). Previous work suggested that the "microtubule binding domain" of tau (composed of three or four imperfect 18-amino acid repeats, separated by 13- or 14-amino acid inter-repeat regions) can bind to the C-terminal ends of both alpha and beta tubulin monomers. Studies revealed that TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded that TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance (2). TUBB1 Protein is ideal for investigators involved in Signaling Proteins, Microtubule/Actin Associated Proteins, Cardiovascular Disease, and Neurobiology research.
TUBB1 Protein is stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. TUBB1 Protein is suitable for use in Western Blot and Kinase Assay. Expect a band approximately ~76kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
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