Troponin I (cTnI) is 1 of 3 subunits, along with troponin C (TnC) and troponin T (TnT) of troponin complex found in cardiac muscle. cTnI binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place, and when cTnI is phosphorylated by protein kinase C and protein kinase A at Ser23/24 it causes regulation of Ca2+- stimulated ATPase. Evidence suggests that phosphorylation of both serines 23 and 24 is required for the reduction in Ca2+-sensitivity and beneficial for relaxation of the heart. Ser23/24 phosphorylation is important for enhanced relaxation in response to prolonged activation of protein kinase C by endothelin in intact myocytes, while Thr144 plays an important role in the acute acceleration of relaxation. Troponin I pS23/24 Antibody is ideal for researchers interested in cancer research.
Anti-Phospho-Ser23/24 Troponin (cardiac) Antibody is stored with 100 μg per ml BSA. It is suitable for Western Blots and is specific for the ~25 kDa cardiac troponin I protein phosphorylated at Ser 23/24. Specific conditions for reactivity should be optimized by the end user.
Type: Primary
Antigen: TNNI3
Clonality: Polyclonal
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Epitope:
Host: Rabbit
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Reactivity: