Trim5 antibody detects rhesus monkey Trim5 alpha. TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5 alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5 alpha; variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5 alpha acts as a natural barrier to cross-species retrovirus transmission. Anti-TRIM5 alpha is ideal for investigators involved in infectious disease research.
Anti-TRIM5 alpha Antibody is suitable for use in E, Wb and IF. Expect a band approximately ~356.3 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
Type: Primary
Antigen: TRIM5
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: