Anti-TRIM25 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

PAB Rabbit TRIM25 HU IgG 100 µg WEST BLOT

PAB Rabbit TRIM25 HU IgG 100 µg WEST BLOT

600-401-FP1

75933-108EA 635.22 USD

75933-108

Anti-TRIM25 Rabbit Polyclonal Antibody

Antibodies

TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.

Anti-TRIM25 Antibody has been tested for use in ELISA, Western Blotting, Immunocytochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 71 kDa in Western Blots of specific cell lysates and tissues.

Type: Primary
Antigen: TRIM25
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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