SIRT2

Supplier: Rockland Immunochemical

009-001-T32S

75931-914EA 380.3 USD

75931-914 75931-916

SIRT2

Proteins and Peptides

SIRT2 control protein-GST fusion

Control Protein
PCA Assays
ImmunoBlot

SIRT2 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT2 being a member of class I. Inhibition of SIRT2 can lead to neuroprotection in cellular and invertebrate models of Huntington's disease (1). Huntington's disease is characterized by increased sterols synthesis in neuronal cells and this process is reversed by SIRT2 inhibition. SIRT2 can deacetylate lys40 of alpha-tubulin both in vitro and in vivo (2). Knockdown of SIRT2 via small interfering RNA results in tubulin hyperacetylation. SIRT2 Protein is ideal for investigators involved in Signaling Proteins, Deacetylase/Demethylase Proteins, Cancer, Cell Cycle, and Inflammation research.

SIRT2 Protein is stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. SIRT2 Protein is suitable for use in Western Blot. Expect a band approximately ~64kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

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