SIRT1

Supplier: Rockland Immunochemical

009-001-T31S

75931-906EA 380.3 USD

75931-906 75931-908

SIRT1

Proteins and Peptides

SIRT1 control protein-GST fusion

Control Protein
PCA Assays
ImmunoBlot

SIRT1 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT1 being a member of class I. SIRT1 is a stress-response and chromatin-silencing factor (1). It is an NAD(+)-dependent histone deacetylase involved in various nuclear events such as transcription, DNA replication, and DNA repair. SIRT1 protein binds and deacetylates the p53 protein (2). Expression of wild type SIRT1 in human cells reduces the transcriptional activity of p53 indicating that SIRT1 is involved in the regulation of p53 function via deacetylation. SIRT1 Protein is ideal for investigators involved in Signaling Proteins, Deacetylase/Demethylase Proteins, Cancer, Cell Cycle, and Inflammation research.

SIRT1 Protein is stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. SIRT1 Protein is suitable for use in Western Blot. Expect a band approximately ~105kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

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