Protein-tyrosine Phosphatase H1 (PTPH1) has recently been identified as a specific p38γ MAPK phosphatase which is mediated through PDZ interaction. Ras has been demonstrated to increase both p38 gamma and PTPH1 protein expression, and there is a coupling of increased p38 gamma and PTPH1 protein expression in primary colon cancer tissues. Phosphorylation of PTPH1 at Ser459 leads to PTPH1 stabilization, which plays an important role in Ras oncogenesis and stress response. Additionally, phosphorylation of PTPH1 Ser459 reveals a novel mechanism by which MAPK signals through PTPH1 to regulate cellular response. PTPH1 pS459 Antibody is ideal for researchers interested in cancer research.
Anti-Phospho-Ser459 PTPH1 Antibody is stored with 100 μg per ml BSA. It is suitable for Western Blots and is specific for the ~104 kDa PTPH1 protein phosphorylated at Ser459. Immunolabeling is blocked by preadsorption Cof the antibody with the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is also completely eliminated by treatment with lambda-phosphatase. Specific conditions for reactivity should be optimized by the end user.
Type: Primary
Antigen: PTPH1
Clonality: Polyclonal
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Host: Rabbit
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