Anti-PIAS1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

Anti-PIAS1 Rabbit Polyclonal Antibody

Anti-PIAS1 Rabbit Polyclonal Antibody

600-401-DM6

75930-930EA 635.22 USD

75930-930

Anti-PIAS1 Rabbit Polyclonal Antibody

Antibodies

The PIAS proteins (protein inhibitor of activated STAT) play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS1. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS1 binds specifically to STAT1, inhibiting STAT1-mediated gene activation and also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS1 is a potent co-activator for CP2c-mediated alpha-globin expression in erythroid cells.

Anti-PIAS1 Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 72 kDa in Western Blots of specific cell lysates and tissues.

Type: Primary
Antigen: PIAS1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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