LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features. Anti-LRRK2 is ideal for researchers interested in Neuroscience, specifically parkinsonism, as well as pathways related to the Electron Transport Chain and Wnt Signaling.
Anti-LRRK2/Dardarin HRP Conjugated Antibody is suitable for Western Blots, Immunocytochemistry, and Immunohistochemistry. Expect a band approximately >200 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
Type: Primary
Antigen: LRRK2
Clonality: Monoclonal
Clone: S231B-34
Conjugation: HRP
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: