Anti-IRAK1 Mouse Monoclonal Antibody [Clone: [8F1A7]]

Supplier: Rockland Immunochemical
200-301-BZ2
75929-218EA 739.7 USD
75929-218
Anti-IRAK1 Mouse Monoclonal Antibody [Clone: [8F1A7]]
Antibodies
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

Anti-IRAK Antibody has been tested for use in ELISA, Western Blotting, and Immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 77 kDa in Western Blots of specific cell lysates and tissues.

Type: Primary
Antigen: IRAK1
Clonality: Monoclonal
Clone: [8F1A7]
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity:
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