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Anti-CD45.1 Mouse Monoclonal Antibody (PE (Phycoerythrin)-Cy7®) [clone: A20]

Supplier: Biogems

07522-77-100

75844-148EA 219.36 USD

75844-148

Anti-CD45.1 Mouse Monoclonal Antibody (PE (Phycoerythrin)-Cy7®) [clone: A20]

Antibodies

The A20 monoclonal antibody reacts with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A). It does not cross-react with cells that express CD45.2. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular regionâ€™s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The A20 antibody inhibits some of the B lymphocytes responses, from CD45.1-expressing mice, to lipopolysaccharides and antigens.

Type: Primary
Antigen: CD45.1
Clonality: Monoclonal
Clone: A20
Conjugation: PE (Phycoerythrin)-Cy7®
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Mouse

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