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Anti-TNFRSF18 Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: DTA-1]

Supplier: Biogems

39612-60-25

75843-366EA 116.13 USD

75843-366

Anti-TNFRSF18 Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: DTA-1]

Antibodies

The DTA-1 monoclonal antibody specifically reacts with mouse Glucocorticoid-Induced TNFR-related protein, also known as GITR and TNFRSF18, a 66-70 kDa homodimer glycoprotein, detected in the T cells treated with glucocorticoid dexamethasone. GITR is also expressed in naÃ¯ve mice by CD25+/CD4+/CD8a- thymocytes and on CD25+/CD4+/CD45RB-low splenocytes. Low levels were detected in splenic CD25+/CD4+/CD45RB-low T cells, B cells, dendritic cells and macrophages. A GITR ligand was detected on dendritic cells, macrophages and B cells.The DTA-1 antibody stimulates GITR and abrogates suppression by T regulatory cells (Treg), without affecting their proliferation. DTA-1 administration or the removal of GITR-expressing cells led to organ specific autoimmune disease.

Type: Primary
Antigen: TNFRSF18
Clonality: Monoclonal
Clone: DTA-1
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Rat
Isotype: IgG2b
Reactivity: Mouse

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