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Anti-PD-1 Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)) [clone: J43.1]

Supplier: Biogems

31812-60-100

75843-272EA 251.63 USD

75843-272

Anti-PD-1 Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)) [clone: J43.1]

Antibodies

The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

Type: Primary
Antigen: PD-1
Clonality: Monoclonal
Clone: J43.1
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Armenian Hamster
Isotype: IgG
Reactivity: Mouse

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