Anti-CD253 Mouse Monoclonal Antibody [clone: RIK-2]

Supplier: BIOGEMS INTERNATIONAL INC.
25611-25-100
75843-258EA 307.14 USD
75843-258
Anti-CD253 Mouse Monoclonal Antibody [clone: RIK-2]
Antibodies
The RIK-2 monoclonal antibody recognizes human CD253, otherwise known as the TNF-related apoptosis inducing ligand (TRAIL) or tumor necrosis factor (ligand) superfamily member 10 (TNFSF10). TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic "death domain", which activates the cell's apoptotic machinery. The RIK-2 antibody is reported to block cellular apoptosis induced by TRAIL.

Type: Primary
Antigen: CD253
Clonality: Monoclonal
Clone: RIK-2
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human
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