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Anti-CD86 (B7-2) (IT2.2) Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: IT2.2]

Supplier: Biogems

08911-60-25

75842-990EA 147.99 USD

75842-990

Anti-CD86 (B7-2) (IT2.2) Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: IT2.2]

Antibodies

The IT2.2 antibody reacts with human CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.The IT2.2 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells. It is reported to be cross-reactive with Rhesus, Cynomolgus and Common marmoset CD86.

Type: Primary
Antigen: CD86 (B7-2) (IT2.2)
Clonality: Monoclonal
Clone: IT2.2
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human

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