Anti-FLT3 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

600-401-BF5

10802-902EA 635.22 USD

10802-902

Anti-FLT3 Rabbit Polyclonal Antibody

Antibodies

FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.

Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: FLT3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Internal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse

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