Anti-SPINK7 Chicken Polyclonal Antibody

Supplier: Rockland Immunochemical

200-901-AY8

10802-566EA 635.22 USD

10802-566

Anti-SPINK7 Chicken Polyclonal Antibody

Antibodies

The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.

Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: 5 ?g/mL; Western Blot: 1 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: SPINK7
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Chicken
Isotype:
Reactivity: Human, Mouse, Rat

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