Anti-DEPTOR Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

Anti-DEPTOR Rabbit polyclonal antibody

Anti-DEPTOR Rabbit polyclonal antibody

600-401-AV0

10802-438EA 635.22 USD

10802-438

Anti-DEPTOR Rabbit Polyclonal Antibody

Antibodies

DEPTOR is an mTOR (mammalian target of rapamycin)-interacting protein whose expression is negatively regualted by mTOR complex 1 (mTORC1) and mTORC2 (1). Loss of DEPTOR activates RP6SK1, Akt1, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities. DEPTOR expression is low in most cancers, but is often elevated in multiple myelomas (1). In respons to stimulation by mitogens, DEPTOR is rapidly phosphorylated leading to its ubiquitination and degradation, allowing mTOR to generate an auto-amplification loop to promotes its own full activation (2).

Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 5 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: DEPTOR
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat

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