Anti-CCDC88A Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

Anti-CCDC88A Rabbit polyclonal antibody

Anti-CCDC88A Rabbit polyclonal antibody

600-401-BK9

10801-692EA 635.22 USD

10801-692

Anti-CCDC88A Rabbit Polyclonal Antibody

Antibodies

Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis. It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning and differentiation of dentate granule cells (DGCs) during development; depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration of mispositioning of DGCs, suggesting the Girdin plays a role in postnatal neurogenesis in the dentate gyrus.

Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: CCDC88A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat

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