Anti-ACVR1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

ACVR1 antibody 100 µg

ACVR1 antibody 100 µg

600-401-X66

10801-658EA 635.22 USD

10801-658

Anti-ACVR1 Rabbit Polyclonal Antibody

Antibodies

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. Unlike ACVR1B and ACVR1C, ACVR1, also known as activin receptor-like kinase 2 (ALK2), can not transduce activin-mediated signaling, but will transduce BMP and Mullerian inhibiting substance (MIS) group signaling. It is thought that ACVR1 also inhibits activin signaling by blocking the binding of activin to its type II receptor. Recent studies indicate that genetic variation in ACVR1 is associated with polycystic ovary syndrome, suggesting that ACVR1 signaling contributes to disturbed folliculogenesis in these patients.

Recommended Dilutions: ELISA: 1:10,000; Western Blot: 1 µg/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: ACVR1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse

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