Anti-AXIN2 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

600-401-Z15

10800-290EA 635.22 USD

10800-290

Anti-AXIN2 Rabbit Polyclonal Antibody

Antibodies

Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: 5 µg/mL; Immunofluorescence Microscopy: 20 µg/mL; Western Blot: 1 µg/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: AXIN2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat

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