Anti-APAF1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

APAF1 (N-term) antibody 100 µg

APAF1 (N-term) antibody 100 µg

600-401-Y26

10800-050EA 635.22 USD

10800-050

Anti-APAF1 Rabbit Polyclonal Antibody

Antibodies

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1). Apaf1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 is ubiquitously expressed in human tissues.

Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: 1 ?g/mL; Immunofluorescence Microscopy: 10 ?g/mL; Western Blot: 1 µg/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: APAF1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat

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