Anti-AFAP1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical

600-401-X77

10799-582EA 635.22 USD

10799-582

Anti-AFAP1 Rabbit Polyclonal Antibody

Antibodies

The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.

Recommended Dilutions: ELISA: 1:10,000-1:20,000; Western Blot: 1 - 2 µg/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: AFAP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse

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