Anti-AAK1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical
600-401-X53
10799-514EA 635.22 USD
10799-514
Anti-AAK1 Rabbit Polyclonal Antibody
Antibodies
AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.

Recommended Dilutions: ELISA: 1:10,000-1:20,000; Western Blot: 1-2 µg/mL; contains 0.02% (w/v) Sodium Azide

Type: Primary
Antigen: AAK1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat
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