Human Recombinant TLR-3 (from HEK293 Cells)

Supplier: Peprotech

160-01-5UG 160-01-25UG 160-01-100UG 160-01-500UG 160-01-1MG

10772-908EA 132.81 USD

10772-908 10772-910 10772-912 10772-916 10772-918

Human Recombinant TLR-3 (from HEK293 Cells)

Proteins and Peptides

TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats, and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane, and in the endosomal compartment of the cells. Recombinant Human TLR-3 is 77.4 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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