Anti-ATG12 Rabbit Polyclonal Antibody

Supplier: Bioss

Anti-ATG12 Rabbit Polyclonal Antibody

Anti-ATG12 Rabbit Polyclonal Antibody

Anti-ATG12 Rabbit Polyclonal Antibody

Anti-ATG12 Rabbit Polyclonal Antibody

BS-4012R

10391-578EA 661.57 USD

10391-578

Anti-ATG12 Rabbit Polyclonal Antibody

Antibodies

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

Recommended Dilutions: IHC-P: 1:100-500; IF(IHC-P): 1:50-200

Type: Primary
Antigen: ATG12
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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