Anti-SATB1 Rabbit Polyclonal Antibody

Supplier: Bioss

BS-1609R
10323-762EA 643.82 USD
10323-762
Anti-SATB1 Rabbit Polyclonal Antibody
Antibodies
Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.

Type: Primary
Antigen: SATB1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Public Immunogen Range: 671-764/764
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse
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