Anti-APOBEC3G Rabbit Polyclonal Antibody (Cy3)

Supplier: Bioss

BS-15407R-CY3
10315-954EA 804.08 USD
10315-954
Anti-APOBEC3G Rabbit Polyclonal Antibody (Cy3)
Antibodies
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.

Type: Primary
Antigen: APOBEC3G
Clonality: Polyclonal
Clone:
Conjugation: Cy3
Public Immunogen Range: 201-300/384
Host: Rabbit
Isotype: IgG
Reactivity: Human
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