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OPG ELISA Assay Kit, Eagle Biosciences

Supplier: Eagle Biosciences

BI-20403

102993-982EA 1131.15 USD

102993-982

OPG ELISA Assay Kit, Eagle Biosciences

Assays ELISAs

Human Osteoprotegerin ELISA detects human osteoprotegerin levels in serum or plasma samples.

Dynamic Range: 0 to 20 pmol/l
Sensitivity: LOD: (0 pmol/l + 3 SD): 0.07 pmol/l; LLOQ: 0.08 pmol/l
Incubation: 5.5 hours

Osteoprotegerin (OPG) or Osteoclast inhibitory factor (OCIF) is a glycoprotein of the TNF receptor superfamily 11b (gene name TNFRSF11B). OPG is synthesized as a monomer of 380 amino acids and is assembled as a homodimer within the cell and then secreted mainly as a disulfide-linked homodimer into the extracellular compartment. OPG is produced by many different tissues and cell types including osteoblasts. OPG is a negative regulator of bone resorption by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis. This glycoprotein is also involved in the regulation of vascular calcification.

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