7-Dehydrocholesterol ≥95%

Supplier: 0000027161

Synonyms: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, 7-DHC

CDX-D0331-G010 CDX-D0331-G025

102989-778EA 113.54 USD

102989-778 102989-780

7-Dehydrocholesterol ≥95%

7-Dehydrocholesterol

Precursor of cholesterol and vitamin D3. It is reduced to cholesterol by the enzyme 3beta-hydroxysterol-Delta7-reductase (DHCR7) in the last step of cholesterol biosynthesis. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome (SLOS). 7-DHC is used as a biomarker for SLOS screenings. Inhibits human fibroblast sphingomyelinase. Shown to have cytotoxic effects on melanoma cells. In skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3. UV/Vis: lambdamax 271, 282, 293nm.

Formula: C₂₇H₄₄O
Storage Temperature: Freezer

MDL Number: MFCD00003624
CAS Number: 434-16-2

Specification Test Results

Source/Host	Synthetic
Purity	95% (HPLC)
Appearance/Color	White powder.
Solubility	Soluble in ethanol, chloroform or ethyl acetate. Slightly soluble in DMSO. Insoluble in water.

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